The Indeterminate Form of Chagas Disease
نویسنده
چکیده
DOI: 10.5935/abc.20180027 The presence of diffuse fibrosis in the myocardial tissue is a characteristic of Chagas heart disease.1 The mechanisms proposed to explain such fibrosis areas vary and include direct injury by Trypanosoma cruzi to the cardiac tissue, as well as tissue ischemia due to microcirculation changes and microvascular thrombosis mediated by inflammatory2 and immune3 processes. The myocardial fibrosis not only reveals important aspects of the pathophysiology of the disease, but has a clinical significance,4 because its progression can lead to injury to the heart conduction system, contributing to generate arrhythmia, as well as systolic and diastolic ventricular dysfunction, in addition to favoring the appearance of thromboembolic phenomena from the hypokinetic or akinetic areas.
منابع مشابه
Scintigraphy for the detection of myocardial damage in the indeterminate form of Chagas disease.
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